HCID 86761997, compound → HCID 86761996, compound

HRID 1890130Notes

Reaction equation

HRID 1890130 reaction equation
[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([P:13]([C:16]3[CH:25]=[C:24]4[C:19]([C:20]([CH3:30])=[CH:21][C:22]([CH3:29])([CH3:28])[N:23]4[CH2:26][CH3:27])=[CH:18][CH:17]=3)(=[O:15])[OH:14])[CH:11]=2)[C:6]([CH3:31])=[CH:5][C:4]1([CH3:33])[CH3:32])[CH3:2]>CO.[Pt]>[CH2:26]([N:23]1[C:24]2[C:19](=[CH:18][CH:17]=[C:16]([P:13]([C:10]3[CH:11]=[C:12]4[C:7]([CH:6]([CH3:31])[CH2:5][C:4]([CH3:33])([CH3:32])[N:3]4[CH2:1][CH3:2])=[CH:8][CH:9]=3)(=[O:14])[OH:15])[CH:25]=2)[CH:20]([CH3:30])[CH2:21][C:22]1([CH3:28])[CH3:29])[CH3:27]

Participants

4

Reactant 1

HCID 86761997HCID 86761997, compound

Product 1

HCID 86761996HCID 86761996, compoundYield 96%

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 887MethanolSolvent

Procedure

To a solution of the compound bis(1-ethyl-2,2,4-trimethyl-1,2-dihydroquinolin-7-yl)phosphinic acid (4.22 g, 9.1 mmol) (Example 5) in methanol (100 mL), was added platinum (0.42 g, 5 wt. % on activated carbon). The mixture was stirred under hydrogen (50 psi) for 5 hours. The mixture was filtered through a pad of celite and then evaporated to dryness to give white solid (4.09 g, 96% yield). It is used without further purification. The structure of bis(1-ethyl-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-7-yl)phosphinic acid is:

Workup

  1. filtrationThe mixture was filtered through a pad of celite
  2. customevaporated to dryness

Sources & evidence

ORD record
ord-aa40eacaa1074e1794e524a57916fbad
Source dataset
uspto-grants-2013_08
Patent number
US08506655B1

Reaction notes

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