Sodium Hydroxide → Ethanol, 2-(1-phenylhydrazino)-

HRID 1890149Notes

Reaction equation

HRID 1890149 reaction equation
C([NH:4][N:5]([CH2:12][CH2:13][OH:14])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)(=O)C.[OH-].[Na+]>Cl>[C:6]1([N:5]([CH2:12][CH2:13][OH:14])[NH2:4])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 10702980HCID 10702980, compound

Product 1

HCID 39491Ethanol, 2-(1-phenylhydrazino)-

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of acetyl-2-(2-hydroxyethyl)-2-phenylhydrazine (i) (0.5 g, 2.57 mmol) in 6N hydrogen chloride 5 ml was refluxed for 2 hours. The reaction was cooled to room temperature and basified with 6N sodium hydroxide to PH 8. The solution was extracted with DCM 2×50 ml, washed with brine 2×30 ml. The organic was dried (MgSO4) and removed in vacuo. The residue was used to next step without further purification.

Workup

  1. extractionThe solution was extracted with DCM 2×50 ml
  2. washwashed with brine 2×30 ml
  3. dry with materialThe organic was dried (MgSO4)
  4. customremoved in vacuo
  5. customThe residue was used to next step without further purification

Sources & evidence

ORD record
ord-dab411e009c543f0a4b977cd3b1a854f
Source dataset
uspto-grants-2013_08
Patent number
US08506932B2

Reaction notes

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