反应详情

温度

70 °C

5-Amino-6-(cyclohexylamino)pyridin-2-yl methanesulfonate (1.44 g, 5.05 mmol) was dissolved in THF (30 mL) and CDI (2.455 g, 15.14 mmol) was added. The mixture was heated at 70° C. for 3 h. THF was removed and the residue was dissolved in EtOAc. The resulting solution was washed with water followed by 1 M HCl, dried over MgSO4 and concentrated under reduced pressure to give the title compound (0.96 g) without further purification. LCMS m/z=312.50 [M+H]+.

1. customTHF was removed
2. dissolutionthe residue was dissolved in EtOAc
3. washThe resulting solution was washed with water
4. dry with materialdried over MgSO4
5. concentrationconcentrated under reduced pressure