Phosphorus oxychloride → HCID 178515750, compound

HRID 1890360Notes

Reaction equation

HRID 1890360 reaction equation
CS([O:5][C:6]1[N:11]=[C:10]2[N:12]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[Br:22])[C:13](O)=[N:14][C:9]2=[CH:8][CH:7]=1)(=O)=O.O=P(Cl)(Cl)[Cl:25]>>[Br:22][C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=1[N:12]1[C:10]2=[N:11][C:6]([OH:5])=[CH:7][CH:8]=[C:9]2[N:14]=[C:13]1[Cl:25]

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178505195HCID 178505195, compound

Product 1

HCID 178515750HCID 178515750, compound

Procedure

From 3-(2-bromophenyl)-2-hydroxy-3H-imidazo[4,5-b]pyridin-5-yl methanesulfonate and POCl3, prepared in a similar manner as the one described in Example 1.136, the title compound was obtained. LCMS m/z=323.90 [M+H]+, 1H NMR (400 MHz, methanol-d4) δ ppm 6.72 (d, J=8.6 Hz, 1H), 7.57-7.65 (m, 3H), 7.90 (dd, J1=8.1 Hz, J2=1.2 Hz, 1H), 7.93 (d, J=8.6 Hz, 1H).

Sources & evidence

ORD record
ord-68d480aca5c9404f8d4184227045659f
Source dataset
uspto-grants-2013_08
Patent number
US08507473B2

Reaction notes

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