反应详情

温度

80 °C

Potassium carbonate (304 mg, 2.2 mmol) is dissolved in a minimum amount of water and 4-fluoro-2-trifluoromethylbenzonitrile (378 mg, 2.0 mmol) and trans-4-aminocyclohexanol (460 mg, 4.0 mmol) dissolved in acetonitrile (10 mL) are added. The reaction is then heated at 80° C. for 3 days. After cooling to room temperature, the mixture is concentrated under reduced pressure, is taken up in ethyl acetate (15 mL) and washed with saturated aqueous ammonium chloride (2×10 mL) followed by water (10 mL). The organic phase is collected and dried over sodium sulphate, filtered and concentrated under reduced pressure. The desired product is isolated as a colourless solid (80% yield).

1. additionare added
2. temperatureAfter cooling to room temperature
3. concentrationthe mixture is concentrated under reduced pressure
4. washwashed with saturated aqueous ammonium chloride (2×10 mL)
5. customThe organic phase is collected
6. dry with materialdried over sodium sulphate
7. filtrationfiltered
8. concentrationconcentrated under reduced pressure