Picolinic acid → HCID 44159005, compound

HRID 1890403Notes

Reaction equation

HRID 1890403 reaction equation
[CH2:1]([O:3][C:4]([N:6]1[CH2:12][CH:11]([NH2:13])[C:10]2=[N:14][C:15]([C:19]3[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=3)=[CH:16][C:17](=[O:18])[N:9]2[CH2:8][CH2:7]1)=[O:5])[CH3:2].[C:25]([O:29][C:30]([N:32]1[CH2:41][CH2:40][C:39]2[C:34](=[CH:35][C:36]([C:42](O)=[O:43])=[CH:37][CH:38]=2)[CH2:33]1)=[O:31])([CH3:28])([CH3:27])[CH3:26].N1C=CC=CC=1C(O)=O>>[CH2:1]([O:3][C:4]([N:6]1[CH2:12][CH:11]([NH:13][C:42]([C:36]2[CH:35]=[C:34]3[C:39]([CH2:40][CH2:41][N:32]([C:30]([O:29][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:31])[CH2:33]3)=[CH:38][CH:37]=2)=[O:43])[C:10]2=[N:14][C:15]([C:19]3[CH:20]=[CH:21][N:22]=[CH:23][CH:24]=3)=[CH:16][C:17](=[O:18])[N:9]2[CH2:8][CH2:7]1)=[O:5])[CH3:2]

Participants

4

Reactant 3

HCID 1018Picolinic acidHCID 189883742-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-7-carboxylic acidHCID 66841894HCID 66841894, compound

Product 1

HCID 44159005HCID 44159005, compound

Procedure

By analogy with the method described in example 1 (step 1.5), using 9-amino-4-oxo-2-pyridin-4-yl-5,6,8,9-tetrahydro-4H-1,4a,7-triaza-benzocycloheptene-7-carboxylic acid ethyl ester and 3,4-dihydro-1H-isoquinoline-2,7-dicarboxylic acid 2-tert-butyl ester in place of (+/−)-9-amino-4-oxo-2-pyrimidin-4-yl-5,6,8,9-tetrahydro-4H-1,4a,7-triaza benzocycloheptene-7-carboxylic acid ethyl ester hydrobromide (1:1) and 2-pyridine carboxylic acid, the compound, 0.286 g (80%), was obtained as a white powder.

Workup

  1. customthe compound, 0.286 g (80%), was obtained as a white powder

Sources & evidence

ORD record
ord-b71e17458f2246b896268e150b74ee5a
Source dataset
uspto-grants-2013_08
Patent number
US08507475B2

Reaction notes

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