HRID1890403

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID1018

Picolinic acid

C6H5NO2

HCID18988374

2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid

C15H19NO4

结构：CCOC(=O)N1CCn2c(nc(-c3ccncc3)cc2=O)C(N)C1

HCID66841894

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)N1CCn2c(nc(-c3ccncc3)cc2=O)C(NC(=O)c2ccc3c(c2)CN(C(=O)OC(C)(C)C)CC3)C1

HCID44159005

未命名化合物

PROCEDURE

实验过程

By analogy with the method described in example 1 (step 1.5), using 9-amino-4-oxo-2-pyridin-4-yl-5,6,8,9-tetrahydro-4H-1,4a,7-triaza-benzocycloheptene-7-carboxylic acid ethyl ester and 3,4-dihydro-1H-isoquinoline-2,7-dicarboxylic acid 2-tert-butyl ester in place of (+/−)-9-amino-4-oxo-2-pyrimidin-4-yl-5,6,8,9-tetrahydro-4H-1,4a,7-triaza benzocycloheptene-7-carboxylic acid ethyl ester hydrobromide (1:1) and 2-pyridine carboxylic acid, the compound, 0.286 g (80%), was obtained as a white powder.

WORKUP

后处理

customthe compound, 0.286 g (80%), was obtained as a white powder

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b71e17458f2246b896268e150b74ee5a
来源数据集: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08507475B2
来源说明: uspto-grants-2013_08

反应 SMILES

[CH2:1]([O:3][C:4]([N:6]1[CH2:12][CH:11]([NH2:13])[C:10]2=[N:14][C:15]([C:19]3[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=3)=[CH:16][C:17](=[O:18])[N:9]2[CH2:8][CH2:7]1)=[O:5])[CH3:2].[C:25]([O:29][C:30]([N:32]1[CH2:41][CH2:40][C:39]2[C:34](=[CH:35][C:36]([C:42](O)=[O:43])=[CH:37][CH:38]=2)[CH2:33]1)=[O:31])([CH3:28])([CH3:27])[CH3:26].N1C=CC=CC=1C(O)=O>>[CH2:1]([O:3][C:4]([N:6]1[CH2:12][CH:11]([NH:13][C:42]([C:36]2[CH:35]=[C:34]3[C:39]([CH2:40][CH2:41][N:32]([C:30]([O:29][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:31])[CH2:33]3)=[CH:38][CH:37]=2)=[O:43])[C:10]2=[N:14][C:15]([C:19]3[CH:20]=[CH:21][N:22]=[CH:23][CH:24]=3)=[CH:16][C:17](=[O:18])[N:9]2[CH2:8][CH2:7]1)=[O:5])[CH3:2]