反应详情

4 ml of pyridine, 550 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride and 700 mg of 2-aminophenol are added to a solution of 500 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate in 4 ml of dimethylformamide. The reaction mixture is stirred at ambient temperature overnight, and is then concentrated under reduced pressure. Water and ethyl acetate are added and the resulting mixture is thus stirred for 30 minutes. The precipitate formed is filtered off, and rinsed with water, ethyl ether and petroleum ether. The solid obtained is dried under vacuum. 370 mg of N-(2-hydroxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are thus obtained in the form of a beige solid, the characteristics of which are the following:

1. concentrationis then concentrated under reduced pressure
2. additionWater and ethyl acetate are added
3. stirringthe resulting mixture is thus stirred for 30 minutes
4. customThe precipitate formed
5. filtrationis filtered off
6. washrinsed with water, ethyl ether and petroleum ether
7. customThe solid obtained
8. customis dried under vacuum