反应详情

The product is prepared according to the procedure described in Stage 2 of Example 2, using 120 mg of N-(4-fluoro-2-hydroxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide, and 11 mg of 4-methylbenzenesulphonic acid hydrate, and replacing the toluene with xylene. After purification by silica gel column chromatography, eluent: CH2Cl2/MeOH: 98/02, 15 mg of 2-[(6-fluoro-1,3-benzoxazol-2-yl)methyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one are obtained in the form of a white solid, the characteristics of which are the following:

1. customThe product is prepared
2. customAfter purification by silica gel column chromatography, eluent