反应详情

The product is prepared according to the procedure described in Example 3, using 300 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 455 mg of N-benzylbenzene-1,2-diamine and 330 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 2.5 ml of pyridine and 2.5 ml of dimethylformamide and then in 5 ml of acetic acid. After refluxing for forty-five minutes and purification by silica column chromatography, eluent: CH2Cl2/MeOH: 95/05, 250 mg of 2-[(1-benzyl-1H-benzimidazol-2-yl)methyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one are obtained in the form of a cream powder, the characteristics of which are the following:

1. customThe product is prepared
2. temperatureAfter refluxing for forty-five minutes
3. custompurification by silica column chromatography, eluent