反应详情

温度

120 °C

To an 8 mL screw cap vial equipped with a magnetic stirring bar were added 5-chlorothiazolo[5,4-b]pyridine (Q-4) (460 mg, 2.7 mmol), Zn(CN)2 (316 mg, 2.7 mmol), Pd2(dba)3 (123 mg, 0.13 mmol), DPPF (150 mg, 0.27 mmol) and DMF (5 mL, wet, containing 1% of H2O). The vial was flushed with nitrogen, then sealed with the screw cap. The mixture was stirred at 120° C. for overnight, and then concentrated in vacuo. The resulting residue was purified by chromatography on silica gel to give the title compound (151 mg).

1. customTo an 8 mL screw cap vial
2. customequipped with a magnetic stirring bar
3. customThe vial was flushed with nitrogen
4. customsealed with the screw
5. customcap
6. concentrationconcentrated in vacuo
7. customThe resulting residue was purified by chromatography on silica gel