反应详情

In step 2-3, a solution of 2-chloro-N-(1-(3-fluorophenyl)-2-hydroxyethyl)acetamide (5.5 g, 24 mmol) in THF (150 mL) was slowly added to a suspension of NaH (1.05 g, 26 mmol) in THF (600 mL) at 0° C. The heterogeneous solution was warmed to room temperature and stirred overnight. The reaction mixtures was quenched, concentrated and ethyl acetate was added to the residue. This solution was washed with water and brine and the organic phase was dried over MgSO4, filtered and concentrated to yield 5-(3-fluorophenyl)morpholin-3-one (2-3).

1. customThe reaction mixtures
2. customwas quenched
3. concentrationconcentrated
4. additionethyl acetate was added to the residue
5. washThis solution was washed with water and brine
6. dry with materialthe organic phase was dried over MgSO4
7. filtrationfiltered
8. concentrationconcentrated