HCID 58550526, compound → HCID 136127571, compound

HRID 1890986Notes

Reaction equation

HRID 1890986 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]1[N:20]=[CH:19][N:18]=[C:17]([NH:21][C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([S:28]([CH3:31])(=[O:30])=[O:29])[CH:23]=2)[CH:16]=1)C1C=CC=CC=1>FC(F)(F)C(O)=O>[CH3:31][S:28]([C:24]1[CH:23]=[C:22]([NH:21][C:17]2[N:18]=[CH:19][N:20]=[C:15]([C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=3[OH:8])[CH:16]=2)[CH:27]=[CH:26][CH:25]=1)(=[O:29])=[O:30]

Participants

3

Reactant 1

HCID 58550526HCID 58550526, compound

Product 1

HCID 136127571HCID 136127571, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A mixture of [6-(2-benzyloxy-phenyl)-pyrimidin-4-yl]-(3-methanesulfonyl-phenyl)-amine (7.90 g, 18.3 mmol) and trifluoroacetic acid (100 mL) was refluxed to completion of the reaction. All the volatiles were evaporated in vacuo, the residue was re-crystallized from ethanol to give 2-[6-(3-methanesulfonyl-phenylamino)-pyrimidin-4-yl]-phenol as white powder.

Workup

  1. temperaturewas refluxed to completion of the reaction
  2. customAll the volatiles were evaporated in vacuo
  3. customthe residue was re-crystallized from ethanol

Sources & evidence

ORD record
ord-310f3a075ee143579160989b91826256
Source dataset
uspto-grants-2013_08
Patent number
US08507498B2

Reaction notes

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