反应详情

温度

60 °C

To a stirred mixture of iron powder (0.5 g), ethanol (20 ml), water (1 ml) and concentrated hydrochloric acid (5 drops) at reflux was added N,N-Dimethyl-C-(3-nitro-phenyl)-methanesulfonamide (0.5 g). The mixture was then heated under reflux for a further 2 hours then basified with excess sodium carbonate solution, cooled to 60° C., then filtered. The filter cake washed with ethanol and the filtrate evaporated. The crude product was partitioned between ethyl acetate and water, separation and evaporation of the organic phase gave C-(3-Amino-phenyl)-N,N-dimethyl-methanesulfonamide, 0.4 g, sufficiently pure to use.

1. temperatureat reflux
2. temperatureThe mixture was then heated
3. temperatureunder reflux for a further 2 hours
4. filtrationfiltered
5. washThe filter cake washed with ethanol
6. customthe filtrate evaporated
7. customThe crude product was partitioned between ethyl acetate and water, separation and evaporation of the organic phase