Hydrochloric Acid → HCID 178517822, compound

HRID 1891071Notes

Reaction equation

HRID 1891071 reaction equation
[Br:1][C:2]1[C:3](Cl)=[N:4][C:5]([Cl:8])=[N:6][CH:7]=1.[OH-:10].[Na+].Cl>>[Br:1][C:2]1[C:3]([OH:10])=[N:4][C:5]([Cl:8])=[N:6][CH:7]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 2899735-Bromo-2,4-dichloropyrimidine

Product 1

HCID 178517822HCID 178517822, compound

Conditions

Temperature
47.5 °C

Procedure

50.5 g of 5-bromo-2,4-dichloropyrimidine is mixed with 133 ml of 2N sodium hydroxide solution and stirred for 50 minutes at 45-50° C. After cooling, it is acidified with 21 ml of concentrated hydrochloric acid while being cooled with ice. The precipitate is suctioned off, washed with water and a little methylene chloride and dried at 25-35° C. 17.12 g (36.9% of theory) of the product with a melting point of 136-145° C. (decomposition) is obtained.

Workup

  1. temperatureAfter cooling
  2. temperaturewhile being cooled with ice
  3. washwashed with water
  4. dry with materiala little methylene chloride and dried at 25-35° C
  5. custom17.12 g (36.9% of theory) of the product with a melting point of 136-145° C. (decomposition) is obtained

Sources & evidence

ORD record
ord-0eb80beacc094ba9a2527bd60891939b
Source dataset
uspto-grants-2013_08
Patent number
US08507510B2

Reaction notes

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