Benzaldehyde → HCID 60130838, compound

HRID 1891308Notes

Reaction equation

HRID 1891308 reaction equation
[CH:1](=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:9][CH:10]1[CH2:14][CH2:13][NH:12][CH2:11]1>C1(C)C=CC=CC=1>[C:2]1([CH:1]=[N:9][CH:10]2[CH2:14][CH2:13][NH:12][CH2:11]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 240BenzaldehydeHCID 1644013-Aminopyrrolidine

Product 1

HCID 60130838HCID 60130838, compoundYield 60.3%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Benzaldehyde (21.2 g; 0.20 mol) was added, dropwise, to a solution of 3-aminopyrrolidine (17.2 g; 0.20 mol) in toluene (80 ml). The solution thus obtained was stirred at room temperature. After 3 h the solvent was removed by evaporation at reduced pressure and the residue was taken up twice with toluene. 21 g N-(phenylmethylene)pyrrolidine-3-amine was thus obtained, and was used in subsequent reactions without further purification.

Workup

  1. customThe solution thus obtained
  2. customAfter 3 h the solvent was removed by evaporation at reduced pressure

Sources & evidence

ORD record
ord-4cde63631a6b4a34aa2ccb4e5ca4a9f9
Source dataset
uspto-grants-2013_08
Patent number
US08507528B2

Reaction notes

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