Tributylstannane → (4-Benzyloxy-benzyl)-tributyl-stannane

Temperature

-78 °C

To a mixture of diisopropylamine (1.1 mL, 7.7 mmol) and tetrahydrofuran (20 mL) was added dropwise n-butyl lithium (1.6 M n-hexane solution, 4.5 mL, 7.1 mmol) at −78° C., which was stirred for 30 minutes at that temperature. Tributyltin hydride (1.7 mL, 6.5 mmol) was added dropwise to the reaction mixture at the same temperature and then stirred for 30 minutes at 0° C. The reaction mixture was cooled to −78° C., and a mixture of 4-benzyloxybenzyl chloride (1.5 g, 6.5 mmol) and tetrahydrofuran (10 mL) was added dropwise at that temperature. The reaction mixture was gradually warmed to room temperature. The reaction mixture was partitioned into water and n-heptane. The organic layer was washed with saturated aqueous sodium chloride, and the solvent was evaporated under a reduced pressure. The residue was purified by neutral silica gel column chromatography (ethyl acetate:heptane=1:30) to obtain the title compound (2.6 g, 83%).

1. stirringstirred for 30 minutes at 0° C
2. additionwas added dropwise at that temperature
3. temperatureThe reaction mixture was gradually warmed to room temperature
4. customThe reaction mixture was partitioned into water and n-heptane
5. washThe organic layer was washed with saturated aqueous sodium chloride
6. customthe solvent was evaporated under a reduced pressure
7. customThe residue was purified by neutral silica gel column chromatography (ethyl acetate:heptane=1:30)

ORD record

ord-f4c42d40edc0453492ff404da8741fb4

Source dataset

uspto-grants-2013_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08507530B2