Hydrochloric Acid → 1-(3-chloro-2-fluorobenzyl)-N-hydroxy-1H-pyrrolo[2,3-c]pyridine-5-carboxamide

HRID 189171Notes

Reaction equation

HRID 189171 reaction equation
[Cl:1][c:2]1[c:3]([F:4])[c:5]([CH2:9][n:10]2[c:11]3[cH:12][n:13][c:14]([C:15]([O:16][CH2:17][CH3:18])=[O:19])[cH:20][c:21]3[cH:22][cH:23]2)[cH:6][cH:7][cH:8]1.[Cl:38][c:39]1[c:40]([F:41])[c:42]([CH2:46][Br:47])[cH:43][cH:44][cH:45]1.[Cl:48][c:49]1[c:50]([F:51])[c:52]([CH2:57][n:58]2[c:59]3[cH:60][n:61][c:62]([C:63]([OH:64])=[O:65])[cH:66][c:67]3[cH:68][cH:69]2)[c:53]([F:54])[cH:55][cH:56]1.[Cl:70][c:71]1[c:72]([F:92])[c:73]([CH2:74][n:75]2[cH:76][cH:77][c:78]3[c:79]2[cH:80][n:81][c:82]([C:84](=[O:85])[NH:86][OH:87])[cH:83]3)[c:88]([F:91])[cH:89][cH:90]1.[Cl:93][c:94]1[c:95]([F:96])[c:97]([CH2:101][n:102]2[c:103]3[cH:104][n:105][c:106]([C:107]([OH:108])=[O:109])[cH:110][c:111]3[cH:112][cH:113]2)[cH:98][cH:99][cH:100]1.[ClH:114].[NH2:115][OH:116].[nH:24]1[c:25]2[cH:26][n:27][c:28]([C:29]([O:30][CH2:31][CH3:32])=[O:33])[cH:34][c:35]2[cH:36][cH:37]1>>[Cl:70][c:71]1[c:72]([F:92])[c:73]([CH2:74][n:75]2[cH:76][cH:77][c:78]3[c:79]2[cH:80][n:81][c:82]([C:84](=[O:85])[NH:86][OH:87])[cH:83]3)[cH:88][cH:89][cH:90]1

Participants

9

Reactant 8

HCID 313Hydrochloric AcidHCID 787HydroxylamineHCID 5228271-(Bromomethyl)-3-chloro-2-fluorobenzeneHCID 100656851-[(3-Chloro-2,6-difluoro-phenyl)methyl]pyrrolo[2,3-c]pyridine-5-carbohydroxamic acidHCID 10702827ethyl 1H-pyrrolo[2,3-c]pyridine-5-carboxylateHCID 218922001-(3-chloro-2-fluorobenzyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acidHCID 21892239Ethyl 1-(3-chloro-2-fluorobenzyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylateHCID 445493881-(3-Chloro-2,6-difluorobenzyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylic Acid

Product 1

HCID 103586011-(3-chloro-2-fluorobenzyl)-N-hydroxy-1H-pyrrolo[2,3-c]pyridine-5-carboxamide

Sources & evidence

ORD record
ord-9bcf2d79c6e9487eb2b37436ab4bf22b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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