Methanol → HCID 86629088, compound

HRID 1891985Notes

Reaction equation

HRID 1891985 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[O:7][CH2:8][C:9]1[CH:31]=[CH:30][C:12]([CH2:13][C:14]2[CH:18]=[C:17]([C:19]3[C:20]([NH:25][P:26](=[O:29])([OH:28])[OH:27])=[N:21][CH:22]=[CH:23][CH:24]=3)[O:16][N:15]=2)=[CH:11][CH:10]=1.CO.O.[OH-].[Li+:36]>O>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[O:7][CH2:8][C:9]1[CH:31]=[CH:30][C:12]([CH2:13][C:14]2[CH:18]=[C:17]([C:19]3[C:20]([NH:25][P:26]([O-:28])([O-:29])=[O:27])=[N:21][CH:22]=[CH:23][CH:24]=3)[O:16][N:15]=2)=[CH:11][CH:10]=1.[Li+:36].[Li+:36]

Participants

5

Reactant 3

HCID 887MethanolHCID 168937Lithium hydroxide, monohydrateHCID 25052753HCID 25052753, compound

Product 1

HCID 86629088HCID 86629088, compoundYield 71.3%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a mixture of (3-(3-(4-((pyridin-2-yloxy)methyl)benzyl)isoxazol-5-yl)pyridin-2-yl)phosphoramidic acid (8.5 mg, 0.019 mmol) described in Example 2 and methanol (1 mL) was added a mixture of lithium hydroxide monohydrate (1.9 mg, 0.045 mmol) and water (4 mL) at room temperature, and the solvent was evaporated from the reaction mixture under a reduced pressure. The resulting residue was washed with methanol to obtain the title compound (6.1 mg, 70%).

Workup

  1. additionwas added
  2. customthe solvent was evaporated from the reaction mixture under a reduced pressure
  3. washThe resulting residue was washed with methanol

Sources & evidence

ORD record
ord-a0a98fd2ddbc4a40af1772f96d43940a
Source dataset
uspto-grants-2013_08
Patent number
US08507530B2

Reaction notes

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