Hydrochloric Acid → HCl MTBD

HRID 1892075Notes

Reaction equation

HRID 1892075 reaction equation
[CH3:1][N:2]1[C:7]2=[N:8][CH2:9][CH2:10][CH2:11][N:6]2[CH2:5][CH2:4][CH2:3]1.[ClH:12]>CCOCC>[ClH:12].[CH3:1][N:2]1[C:7]2=[N:8][CH2:9][CH2:10][CH2:11][N:6]2[CH2:5][CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 1235837-Methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene

Product 1

HCID 131730803HCl MTBD

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A flame dried flask was charged with MTBD (0.25 g, 1.63 mmol), ether (10 mL) and a stirbar under dry nitrogen atmosphere. With vigorous stirring a 1M ethereal HCl solution (1.6 mL) was then added to form a white precipitate. Stirring was continued for 1 hour then excess solvent was decanted to yield 0.29 g (94%). The salt was then dried under high vacuum.

Workup

  1. customA flame dried flask
  2. additionwas then added
  3. customto form a white precipitate
  4. customexcess solvent was decanted
  5. customto yield 0.29 g (94%)
  6. customThe salt was then dried under high vacuum

Sources & evidence

ORD record
ord-6cd5d35aca5b4ce79e9dae5ea4099b85
Source dataset
uspto-grants-2013_08
Patent number
US08507640B2

Reaction notes

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