Hydrochloric Acid → HCID 68727146, compound

HRID 1892121Notes

Reaction equation

HRID 1892121 reaction equation
[CH3:1][C:2]1[C:10]2[C:9]([N:11]3[CH2:17][CH:16]4[N:18](C(OC(C)(C)C)=O)[CH:13]([CH2:14][CH2:15]4)[CH2:12]3)=[N:8][CH:7]=[N:6][C:5]=2[NH:4][CH:3]=1.[ClH:26]>O1CCOCC1>[ClH:26].[ClH:26].[CH:16]12[NH:18][CH:13]([CH2:14][CH2:15]1)[CH2:12][N:11]([C:9]1[C:10]3[C:2]([CH3:1])=[CH:3][NH:4][C:5]=3[N:6]=[CH:7][N:8]=1)[CH2:17]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66898703HCID 66898703, compound

Product 1

HCID 68727146HCID 68727146, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Boc-protected diazabicyclo[3.2.1]octane from step A was dissolved in 4M HCl in dioxane (4 ml). The reaction was stirred for 1 hour and concentrated under vacuum to afford 4-(3,8-diazabicyclo[3.2.1]octan-3-yl)-5-methyl-7H-pyrrolo[2,3-d]pyrimidine dihydrochloride (30 mg, 0.093 mmol, 91%).

Workup

  1. concentrationconcentrated under vacuum

Sources & evidence

ORD record
ord-6218b38895184b3b820c6e8e612c1d89
Source dataset
uspto-grants-2013_08
Patent number
US08507672B2

Reaction notes

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