Hydrazine hydrate (1:1) → tert-Butyl 4-(aminooxy)piperidine-1-carboxylate

HRID 1892292Notes

Reaction equation

HRID 1892292 reaction equation
O=C1C2C(=CC=CC=2)C(=O)[N:3]1[O:12][CH:13]1[CH2:18][CH2:17][N:16]([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH2:15][CH2:14]1.O.NN>>[NH2:3][O:12][CH:13]1[CH2:14][CH2:15][N:16]([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH2:17][CH2:18]1

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 21751544Tert-butyl 4-(1,3-dioxoisoindolin-2-yloxy)piperidine-1-carboxylate

Product 1

HCID 24729482tert-Butyl 4-(aminooxy)piperidine-1-carboxylateYield 85%

Procedure

The title compound was prepared from tert-butyl 4-(1,3-dioxoisoindolin-2-yloxy)piperidine-1-carboxylate and hydrazine monohydrate in 85% yield using the same procedure as described in the synthesis of intermediate G

Sources & evidence

ORD record
ord-ebc95ac13ed64307a27bbdc49a3cc3da
Source dataset
uspto-grants-2013_08
Patent number
US08507676B2

Reaction notes

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