反应详情

2 mL of 3N HCl solution was added to a solution of 3-[1-(4,6-difluoro-1-methyl-1H-indazol-5-yl)-ethyl]-6-(1-ethoxy-vinyl)-imidazo[1,2-b]pyridazine in 10 mL of MeOH. The reaction solution was stirred at rt for 3 h and then neutralized with saturated NaHCO3 solution. Solvent was evaporated and the residue was purified by chromatography (DCM: MeOH=10:1) to give the title compound as yellow solid (30 mg, 41%). LCMS (method C): [MH]+=355.9, tR=3.75 min.

1. customSolvent was evaporated
2. customthe residue was purified by chromatography (DCM: MeOH=10:1)