Benzaldehyde → HCID 44439950, compound

HRID 1892829Notes

Reaction equation

C(O[C:6]([NH:8][CH2:9][CH:10]([CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[C:11]([OH:13])=O)=[O:7])(C)(C)C.[CH:21](=O)C1C=CC=CC=1.[Cl:29][C:30]1[CH:35]=[CH:34][C:33]([S:36]([NH2:39])(=[O:38])=[O:37])=[CH:32][CH:31]=1>>[CH2:14]([CH:10]1[CH2:9][NH:8][C:6](=[O:7])[CH2:21][N:39]([S:36]([C:33]2[CH:32]=[CH:31][C:30]([Cl:29])=[CH:35][CH:34]=2)(=[O:37])=[O:38])[C:11]1=[O:13])[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

Participants

Reactant 3

HCID 240Benzaldehyde

HCID 668244-Chlorobenzenesulfonamide

HCID 226142062-Benzyl-3-[(tert-butoxycarbonyl)amino]propanoic acid

Product 1

HCID 44439950HCID 44439950, compound

Procedure

N-(tert-butoxycarbonyl)-2-benzyl-β-alanine synthesized by using benzaldehyde as the starting material for the similar procedure as in Reference Examples 2 to 5, Reference Example 23, and Reference Example 33 was used instead of the starting material of Reference Example 148, that is, the compound S33, and 4-chlorobenzenesulfonamide was used instead of 4-nitrobenzenesulfonamide for the similar procedure as in Reference Example 148 to Reference Example 150 and Example 173 to obtain the title compound.

Sources & evidence

ORD record: ord-7bab5b0041d745edbfa0bf162c032ae3
Source dataset: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08507714B2

Reaction notes

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