1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 49763806, compound

HRID 1893238Notes

Reaction equation

HRID 1893238 reaction equation
CCN=C=NCCCN(C)C.OC(C(F)(F)F)=O.[NH2:19][C:20]1[CH:25]=[CH:24][C:23]([CH:26]2[CH2:31][CH2:30][CH:29]([N:32]3[CH2:35][CH:34]([NH2:36])[CH2:33]3)[CH2:28][CH2:27]2)=[CH:22][CH:21]=1.[F:37][C:38]([F:53])([F:52])[C:39]1[CH:40]=[C:41]([CH:49]=[CH:50][CH:51]=1)[C:42]([NH:44][CH2:45][C:46](O)=[O:47])=[O:43]>>[NH2:19][C:20]1[CH:25]=[CH:24][C:23]([CH:26]2[CH2:27][CH2:28][CH:29]([N:32]3[CH2:33][CH:34]([NH:36][C:46]([CH2:45][NH:44][C:42](=[O:43])[C:41]4[CH:49]=[CH:50][CH:51]=[C:39]([C:38]([F:53])([F:37])[F:52])[CH:40]=4)=[O:47])[CH2:35]3)[CH2:30][CH2:31]2)=[CH:22][CH:21]=1

Participants

4

Reactant 3

HCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 2777432((3-(Trifluoromethyl)benzoyl)amino)acetic acidHCID 86646679HCID 86646679, compound

Product 1

HCID 49763806HCID 49763806, compound

Procedure

The title compound was prepared as a white solid from an EDCI coupling of 1-[4-(4-amino-phenyl)-cyclohexyl]-azetidin-3-ylamine TFA salt (as prepared in the previous step) and (3-trifluoromethyl-benzoylamino)-acetic acid using the procedure described in Step F of Example 1.

Sources & evidence

ORD record
ord-079d5046ac8443fdb3526e53c148060d
Source dataset
uspto-grants-2013_08
Patent number
US08513229B2

Reaction notes

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