Trifluoroacetic acid → 2-Amino-N-[1-(4-phenyl-cyclohexyl)-azetidin-3-yl]-acetamide TFA salt

HRID 1893302Notes

Reaction equation

HRID 1893302 reaction equation
[C:1]([OH:7])([C:3]([F:6])([F:5])[F:4])=[O:2].C(OC(=O)[NH:14][CH2:15][C:16](=[O:34])[NH:17][CH:18]1[CH2:21][N:20]([CH:22]2[CH2:27][CH2:26][CH:25]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)[CH2:24][CH2:23]2)[CH2:19]1)(C)(C)C>>[OH:7][C:1]([C:3]([F:6])([F:5])[F:4])=[O:2].[NH2:14][CH2:15][C:16]([NH:17][CH:18]1[CH2:21][N:20]([CH:22]2[CH2:27][CH2:26][CH:25]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)[CH2:24][CH2:23]2)[CH2:19]1)=[O:34]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59541886{[1-(4-Phenyl-cyclohexyl)-azetidin-3-ylcarbamoyl]-methyl}-carbamic acid tert-butyl ester

Product 1

HCID 866466812-Amino-N-[1-(4-phenyl-cyclohexyl)-azetidin-3-yl]-acetamide TFA salt

Procedure

The title compound was prepared as colorless oil from the TFA de-protection of {[1-(4-phenyl-cyclohexyl)-azetidin-3-ylcarbamoyl]-methyl}-carbamic acid tert-butyl ester (as prepared in the previous step) using the procedure described in step E of Example 1.

Workup

  1. customas prepared in the previous step)

Sources & evidence

ORD record
ord-412f630f983a4389bc1556ae71c4975c
Source dataset
uspto-grants-2013_08
Patent number
US08513229B2

Reaction notes

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