Trifluoroacetic acid → N-(Azetidin-3-ylcarbamoylmethyl)-4-fluoro-3-trifluoromethyl-benzamide TFA Salt

HRID 1893309Notes

Reaction equation

HRID 1893309 reaction equation
[C:1]([OH:7])([C:3]([F:6])([F:5])[F:4])=[O:2].C(OC([N:15]1[CH2:18][CH:17]([NH:19][C:20](=[O:36])[CH2:21][NH:22][C:23](=[O:35])[C:24]2[CH:29]=[CH:28][C:27]([F:30])=[C:26]([C:31]([F:34])([F:33])[F:32])[CH:25]=2)[CH2:16]1)=O)(C)(C)C>>[OH:7][C:1]([C:3]([F:6])([F:5])[F:4])=[O:2].[NH:15]1[CH2:18][CH:17]([NH:19][C:20]([CH2:21][NH:22][C:23](=[O:35])[C:24]2[CH:29]=[CH:28][C:27]([F:30])=[C:26]([C:31]([F:33])([F:34])[F:32])[CH:25]=2)=[O:36])[CH2:16]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 595419223-[2-(4-Fluoro-3-trifluoromethyl-benzoylamino)-acetylamino]-azetidine-1-carboxylic acid tert-butylester

Product 1

HCID 86646682N-(Azetidin-3-ylcarbamoylmethyl)-4-fluoro-3-trifluoromethyl-benzamide TFA Salt

Procedure

The title compound was prepared as colorless oil from the TFA de-protection of 3-[2-(4-fluoro-3-trifluoromethyl-benzoylamino)-acetylamino]-azetidine-1-carboxylic acid tert-butylester (as prepared in the previous step) using the procedure described in Step E of Example 1.

Workup

  1. customas prepared in the previous step)

Sources & evidence

ORD record
ord-8c6cfddc8b3b42a08e72d240f58a4030
Source dataset
uspto-grants-2013_08
Patent number
US08513229B2

Reaction notes

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