4-Phenylcyclohexanone → 4-Fluoro-N-{[1-(4-phenyl-cyclohexyl)-azetidin-3-ylcarbamoyl]-methyl}-3-trifluoromethyl-benzamide
Reaction equation
[C:1]1([CH:7]2[CH2:12][CH2:11][C:10](=O)[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH:14]1[CH2:17][CH:16]([NH:18][C:19]([CH2:21][NH:22][C:23](=[O:35])[C:24]2[CH:29]=[CH:28][C:27]([F:30])=[C:26]([C:31]([F:34])([F:33])[F:32])[CH:25]=2)=[O:20])[CH2:15]1>>[F:30][C:27]1[CH:28]=[CH:29][C:24]([C:23]([NH:22][CH2:21][C:19](=[O:20])[NH:18][CH:16]2[CH2:15][N:14]([CH:10]3[CH2:11][CH2:12][CH:7]([C:1]4[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=4)[CH2:8][CH2:9]3)[CH2:17]2)=[O:35])=[CH:25][C:26]=1[C:31]([F:34])([F:32])[F:33]Participants
3
Procedure
The title compound was prepared as a white solid by reductive amination of 4-phenyl-cyclohexanone (as prepared in the previous step) and N-(azetidin-3-ylcarbamoylmethyl)-4-fluoro-3-trifluoromethyl-benzamide using the procedure described in Step C of Example 4.
Sources & evidence
- ORD record
- ord-a942ea2419e24e2f9abfce024983a14f
- Source dataset
- uspto-grants-2013_08
- Patent number
- US08513229B2
Reaction notes
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