4-Phenylcyclohexanone → 3-Fluoro-N-{[1-(4-phenyl-cyclohexyl)-azetidin-3-ylcarbamoyl]-methyl}-5-trifluoromethyl-benzamide

HRID 1893318Notes

Reaction equation

HRID 1893318 reaction equation
[C:1]1([CH:7]2[CH2:12][CH2:11][C:10](=O)[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH:14]1[CH2:17][CH:16]([NH:18][C:19]([CH2:21][NH:22][C:23](=[O:35])[C:24]2[CH:29]=[C:28]([F:30])[CH:27]=[C:26]([C:31]([F:34])([F:33])[F:32])[CH:25]=2)=[O:20])[CH2:15]1>>[F:30][C:28]1[CH:29]=[C:24]([CH:25]=[C:26]([C:31]([F:34])([F:32])[F:33])[CH:27]=1)[C:23]([NH:22][CH2:21][C:19](=[O:20])[NH:18][CH:16]1[CH2:17][N:14]([CH:10]2[CH2:11][CH2:12][CH:7]([C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)[CH2:8][CH2:9]2)[CH2:15]1)=[O:35]

Participants

3

Reactant 2

HCID 786054-PhenylcyclohexanoneHCID 59361623HCID 59361623, compound

Product 1

HCID 497633433-Fluoro-N-{[1-(4-phenyl-cyclohexyl)-azetidin-3-ylcarbamoyl]-methyl}-5-trifluoromethyl-benzamide

Procedure

The title compound was prepared as a white solid by reductive amination of 4-phenyl-cyclohexanone (Aldrich) and N-(azetidin-3-ylcarbamoylmethyl)-5-fluoro-3-trifluoromethyl-benzamide (as prepared in the previous step) using the procedure described in Step C of Example 4.

Workup

  1. customas prepared in the previous step)

Sources & evidence

ORD record
ord-0dc24102772740c99770ecc21a74293e
Source dataset
uspto-grants-2013_08
Patent number
US08513229B2

Reaction notes

Loading…