反应详情

To a suspension of 2-piperazinone (5.3 g, 52.9 mmol) in dry dichloromethane (DCM) (76 ml) was added triethylamine (16.23 ml, 116 mmol) and finally 2,3-dichlorobenzoyl chloride (12.20 g, 58.2 mmol) dropwise (exothermic). The mixture was stirred at room temperature. After 1 hour the mixture was diluted with DCM (150 mL) and sat. NaHCO3 (150 ml), the phases were separated and the aqueous layer extracted with DCM (2×100 ml). The combined organic fractions were washed with brine and dried over MgSO4. Evaporation gave 4-[(2,3-dichlorophenyl)carbonyl]-2-piperazinone (12 g).

1. customthe phases were separated
2. extractionthe aqueous layer extracted with DCM (2×100 ml)
3. washThe combined organic fractions were washed with brine
4. dry with materialdried over MgSO4
5. customEvaporation