Chlorosuccinimide → 2,3-Dichloro-7-[(2,4-dichlorophenyl)carbonyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine

HRID 1893424Notes

Reaction equation

HRID 1893424 reaction equation
[Cl:1][C:2]1[N:6]2[CH2:7][CH2:8][N:9]([C:11]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=3[Cl:20])=[O:12])[CH2:10][C:5]2=[N:4][CH:3]=1.C1C(=O)N([Cl:28])C(=O)C1>CN(C)C=O>[Cl:28][C:3]1[N:4]=[C:5]2[CH2:10][N:9]([C:11]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=3[Cl:20])=[O:12])[CH2:8][CH2:7][N:6]2[C:2]=1[Cl:1]

Participants

4

Reactant 2

HCID 31398ChlorosuccinimideHCID 497855443-Chloro-7-[(2,4-dichlorophenyl)carbonyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine

Product 1

HCID 497853692,3-Dichloro-7-[(2,4-dichlorophenyl)carbonyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

3-Chloro-7-[(2,4-dichlorophenyl)carbonyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine (E44) (300 mg, 0.907 mmol) and NCS (133 mg, 0.998 mmol) were stirred at RT for 16 h in N,N-dimethylformamide (DMF) (2 mL). Solvents were removed in vacuo and the residue was purified by MDAP to afford desired product in 218 mg.

Workup

  1. customSolvents were removed in vacuo
  2. customthe residue was purified by MDAP

Sources & evidence

ORD record
ord-618783c4af4f40a796e4693773344cd3
Source dataset
uspto-grants-2013_08
Patent number
US08513248B2

Reaction notes

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