反应详情

4-Bromo-2-(1H-imidazol-1-yl)-5-(trifluoromethyl)aniline (12.65 g, 0.0413 mol) is stirred under nitrogen with N,N-carbonyldiimidazole (13.8 g, 0.0825 mol) at 135° C. for 7 hours. After being cooled down to room temperature, the mixture is filtered to yield a grey solid, which is suspended in ethyl acetate (500 mL) and stirred at reflux for 10 minutes. After filtration at room temperature, the solid is washed with ethyl acetated (200 mL) and dried under vacuum to afford the title compound as a grey powder (9.5 g, 69.2%)

1. filtrationthe mixture is filtered
2. customto yield a grey solid, which
3. temperatureat reflux for 10 minutes
4. filtrationAfter filtration at room temperature
5. washthe solid is washed with ethyl
6. customdried under vacuum