反应详情

A solution of N-benzyl-4-chloro-7-(trifluoromethyl)imidazo[1,2-a]quinoxalin-8-amine (30 mg; 0.079 mmol; 1 eq), 3-propanolamine (20 μl; 0.264 mmol; 3.3 eq) and diisopropylethylamine (15 μl; 0.088 mmol; 1.1 eq) in anhydrous 1,4-dioxane (0.5 ml) is stirred under argon at 100° C. for 16 h. Partition (ethyl acetate/aqueous ammonium chloride), washings of the organic phase (twice with aqueous ammonium chloride, once with brine), drying (magnesium sulfate) and concentration affords the title product (28 mg; 0.067 mmol; 86%) as a white solid.

1. customPartition (ethyl acetate/aqueous ammonium chloride), washings of the organic phase (twice with aqueous ammonium chloride
2. dry with materialonce with brine), drying
3. concentration(magnesium sulfate) and concentration