反应详情

The compound (837 mg, 2.53 mmol) obtained in step B was added to ethanol (20 ml), hydrazine monohydrate (0.31 ml, 6.4 mmol) was added, and the mixture was heated under reflux for 1 hr. The reaction mixture was cooled, and diethyl ether was added to allow precipitation of a solid. The precipitated solid was filtered, and the obtained solution was concentrated under reduced pressure to give a colorless oil. The oil was dissolved in diethyl ether, 4N hydrochloric acid-dioxane solution (1 ml) was added at room temperature and the mixture was diluted with ethyl acetate to allow precipitation of a solid. This was filtered, washed with ethyl acetate, and dried under reduced pressure to give the title compound (598 mg, yield 100%) as a colorless solid.

1. additionwas added
2. temperaturethe mixture was heated
3. temperatureunder reflux for 1 hr
4. temperatureThe reaction mixture was cooled
5. customprecipitation of a solid
6. filtrationThe precipitated solid was filtered
7. concentrationthe obtained solution was concentrated under reduced pressure
8. customto give a colorless oil
9. customprecipitation of a solid
10. filtrationThis was filtered
11. washwashed with ethyl acetate
12. customdried under reduced pressure