Diisopropylethylamine → HCID 123242916, compound

HRID 1893581Notes

Reaction equation

HRID 1893581 reaction equation
[CH2:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][N:2]1[N:10]([CH3:32])[C:11](=[O:31])[CH2:12][N:13]([C:18]1[CH:23]=[C:22]([C:24]2[N:28]=[C:27]([CH3:29])[O:26][N:25]=2)[CH:21]=[CH:20][C:19]=1[CH3:30])[CH2:14][C:15](O)=[O:16].Br.[Br:34][CH2:35][CH2:36][NH2:37].C(N(CC)C(C)C)(C)C>>[CH2:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[CH2:1][N:2]1[N:10]([CH3:32])[C:11](=[O:31])[CH2:12][N:13]([C:18]1[CH:23]=[C:22]([C:24]2[N:28]=[C:27]([CH3:29])[O:26][N:25]=2)[CH:21]=[CH:20][C:19]=1[CH3:30])[CH2:14][C:15]([NH:37][CH2:36][CH2:35][Br:34])=[O:16]

Participants

4

Reactant 3

HCID 81531DiisopropylethylamineHCID 27742172-Bromoethylamine hydrobromideHCID 66880943HCID 66880943, compound

Product 1

HCID 123242916HCID 123242916, compoundYield 70%

Procedure

Using the compound (1.24 g, 2.85 mmol) of Example 15, step A, 2-bromoethylamine hydrobromide (786 mg, 3.84 mmol), and N,N-diisopropylethylamine (0.70 ml, 4.1 mmol), and according to the method of Example 1, step B, the title compound (1.08 g, yield 70%) was obtained as a colorless solid.

Sources & evidence

ORD record
ord-6a6558df8db34996a7ef0440490eadf2
Source dataset
uspto-grants-2013_08
Patent number
US08513235B2

Reaction notes

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