Hydrochloric Acid → HCID 66881527, compound

HRID 1893595Notes

Reaction equation

HRID 1893595 reaction equation
C([O:3][C:4](=O)[CH2:5][N:6]([CH2:18][C:19]([N:21]([N:23]1[CH2:31][C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH2:24]1)[CH3:22])=[O:20])[C:7]1[C:15]([CH3:16])=[CH:14][C:13]2[C:9](=[CH:10][N:11]([CH3:17])[N:12]=2)[CH:8]=1)C.[OH-:33].[Na+].Cl>CO.O1CCCC1>[CH2:31]1[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH2:24][N:23]1[N:21]([CH3:22])[C:19](=[O:20])[CH2:18][N:6]([C:7]1[CH:8]=[C:9]2[C:10](=[CH:14][C:15]=1[CH3:16])[N:11]([CH3:17])[N:12]=[CH:13]2)[CH2:5][C:4]([OH:3])=[O:33]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 66880782HCID 66880782, compound

Product 1

HCID 66881527HCID 66881527, compoundYield 88%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

The compound (631 mg, 1.45 mmol) of step C was dissolved in a methanol (5 ml)-tetrahydrofuran (2 ml) mixed solvent, 1N sodium hydroxide (5 ml) was added at room temperature, and the mixture was stirred at room temperature for 70 min. To the reaction mixture was added 1N hydrochloric acid (5 ml), and the solution was concentrated under reduced pressure. The precipitated solid was filtered, washed with water, and dried under reduced pressure to give the title compound (517 mg, yield 88%) as a colorless solid.

Workup

  1. additionwas added at room temperature
  2. concentrationthe solution was concentrated under reduced pressure
  3. filtrationThe precipitated solid was filtered
  4. washwashed with water
  5. customdried under reduced pressure

Sources & evidence

ORD record
ord-fd84eb5c5a03441e935872e9883f94d1
Source dataset
uspto-grants-2013_08
Patent number
US08513235B2

Reaction notes

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