反应详情

8-Isopropyl-4-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one (5.38 g, 21.59 mmol) was dissolved in 100 mL DCM. To the stirring solution, m-CPBA (13.97 g, 64.78 mmol) was added. The reaction was allowed to stir for 2.5 h at room temperature. LCMS indicated reaction had gone to completion. Sample was diluted with 300 mL of DCM and 300 mL K2CO3, upon addition of base a white precipitate formed that dissolved in excess H2O. Organic layer was extracted further with H2O and brine, and then dried over Na2CO3. The solvent was evaporated to afford the product 8-isopropyl-4-methyl-2-(methylsulfonyl)pyrido[2,3-d]pyrimidin-7(8H)-one (6.0 g, 99% yield) as a light yellow oil that was used immediately in the next reaction.

1. customreaction
2. customformed
3. extractionOrganic layer was extracted further with H2O and brine
4. dry with materialdried over Na2CO3
5. customThe solvent was evaporated