Tetrahydrofuran → 8-[[5-(4-Ethyl-1-piperazinyl)-2-(trifluoromethoxy)phenyl]amino]-4,5-dihydro-1-methyl-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide
Reaction equation
[CH2:59]([CH3:60])[N:61]1[CH2:62][CH2:63][NH:64][CH2:65][CH2:66]1.[CH2:67]1[O:68][CH2:69][CH2:70][CH2:71]1.[CH:1]1([P:2]([CH:3]2[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]2)[c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]2-[c:15]2[cH:16][cH:17][cH:18][cH:19][c:20]2[N:21]([CH3:22])[CH3:23])[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28]1.[F:29][C:30]([O:31][c:32]1[c:33]([NH:39][c:40]2[n:41][c:42]3[c:47]([cH:48][n:49]2)[CH2:46][CH2:45][c:44]2[c:43]-3[n:52]([CH3:53])[n:51][c:50]2[C:54](=[O:55])[NH2:56])[cH:34][c:35]([Br:38])[cH:36][cH:37]1)([F:57])[F:58].[O:110]=[C:111]([CH:112]=[CH:113][c:114]1[cH:115][cH:116][cH:117][cH:118][cH:119]1)[CH:120]=[CH:121][c:122]1[cH:123][cH:124][cH:125][cH:126][cH:127]1.[O:74]=[C:75]([CH:76]=[CH:77][c:78]1[cH:79][cH:80][cH:81][cH:82][cH:83]1)[CH:84]=[CH:85][c:86]1[cH:87][cH:88][cH:89][cH:90][cH:91]1.[O:92]=[C:93]([CH:94]=[CH:95][c:96]1[cH:97][cH:98][cH:99][cH:100][cH:101]1)[CH:102]=[CH:103][c:104]1[cH:105][cH:106][cH:107][cH:108][cH:109]1.[Pd:72].[Pd:73]>>[F:29][C:30]([O:31][c:32]1[c:33]([NH:39][c:40]2[n:41][c:42]3[c:47]([cH:48][n:49]2)[CH2:46][CH2:45][c:44]2[c:43]-3[n:52]([CH3:53])[n:51][c:50]2[C:54](=[O:55])[NH2:56])[cH:34][c:35]([N:64]2[CH2:63][CH2:62][N:61]([CH2:59][CH3:60])[CH2:66][CH2:65]2)[cH:36][cH:37]1)([F:57])[F:58]Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-264f5c19da334394929fafa1b32ed094
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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