Hydrochloric Acid → HCID 66686258, compound

HRID 1894283Notes

Reaction equation

HRID 1894283 reaction equation
[CH3:1][C:2]1[NH:10][C:9]2[CH:8]=[CH:7][N:6]=[C:5]([NH:11][CH2:12][C:13]3[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=3)[C:4]=2[C:3]=1[CH3:20].[ClH:21]>C(OCC)(=O)C>[ClH:21].[CH3:1][C:2]1[NH:10][C:9]2[CH:8]=[CH:7][N:6]=[C:5]([NH:11][CH2:12][C:13]3[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=3)[C:4]=2[C:3]=1[CH3:20]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 11708802HCID 11708802, compound

Product 1

HCID 66686258HCID 66686258, compoundYield 82.5%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

2,3-dimethyl-4-(4-fluorobenzylamino)-1H-pyrrolo[3,2-c]pyridine (1.44 g, 5.34 mmol) prepared in Example 32 was dissolved in ethyl acetate (10 ml). The reaction mixture was saturated with hydrochloric acid gas and then filtered to give the titled compound as a white solid. (Yield: 82.5%)

Workup

  1. filtrationfiltered

Sources & evidence

ORD record
ord-f67c5bd23f8e448a9f7a35810d9806e6
Source dataset
uspto-grants-2013_08
Patent number
US08513277B2

Reaction notes

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