Iodoethane → HCID 57669997, compound

HRID 1894467Notes

Reaction equation

[C:1]([C:5]1[N:10]=[CH:9][C:8]([C:11]2[N:12]([C:32]([N:34]3[CH2:39][CH2:38][N:37]([CH2:40][C:41]([NH:43][C:44]4[CH:45]=[N:46][CH:47]=[CH:48][CH:49]=4)=[O:42])[CH2:36][CH2:35]3)=[O:33])[C@@:13]([C:25]3[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][CH:26]=3)([CH3:24])[C@@:14]([C:17]3[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=3)([CH3:16])[N:15]=2)=[C:7]([O:50][CH2:51][CH3:52])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[CH2:53](I)[CH3:54].[H-].[Na+]>>[C:1]([C:5]1[N:10]=[CH:9][C:8]([C:11]2[N:12]([C:32]([N:34]3[CH2:35][CH2:36][N:37]([CH2:40][C:41]([N:43]([CH2:53][CH3:54])[C:44]4[CH:45]=[N:46][CH:47]=[CH:48][CH:49]=4)=[O:42])[CH2:38][CH2:39]3)=[O:33])[C@@:13]([C:25]3[CH:26]=[CH:27][C:28]([Cl:31])=[CH:29][CH:30]=3)([CH3:24])[C@@:14]([C:17]3[CH:18]=[CH:19][C:20]([Cl:23])=[CH:21][CH:22]=3)([CH3:16])[N:15]=2)=[C:7]([O:50][CH2:51][CH3:52])[CH:6]=1)([CH3:2])([CH3:3])[CH3:4]

Participants

Reactant 3

HCID 6340Iodoethane

HCID 24758Sodium hydride

HCID 57669987HCID 57669987, compound

Product 1

HCID 57669997HCID 57669997, compound

Procedure

2-{4-[(4S,5R)-2-(6-tert-Butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-N-pyridin-3-yl-acetamide (example 127) was treated with ethyl iodide (Aldrich) and sodium hydride to give the title compound. HR-MS (ES, m/z) calculated for C42H50Cl2N7O3 [(M+H)+] 770.3347, observed 770.3347.

Sources & evidence

ORD record: ord-f607580f3a1a4721be3b52086398dc78
Source dataset: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08513239B2

Reaction notes

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