Dimethylformamide → 2,4,6-Trifluorobenzoyl chloride

HRID 1894705Notes

Reaction equation

HRID 1894705 reaction equation
[F:1][C:2]1[CH:10]=[C:9]([F:11])[CH:8]=[C:7]([F:12])[C:3]=1[C:4](O)=[O:5].CN(C=O)C.C(Cl)(=O)C([Cl:21])=O>C(Cl)Cl>[F:1][C:2]1[CH:10]=[C:9]([F:11])[CH:8]=[C:7]([F:12])[C:3]=1[C:4]([Cl:21])=[O:5]

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 5203732,4,6-Trifluorobenzoic acid

Product 1

HCID 1448952,4,6-Trifluorobenzoyl chloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a DCM 200 mL solution of 2,4,6-trifluorobenzoic acid (20 g, 0.11 mol) and DMF (0.5 mL, 6.46 mmol) was added oxalyl chloride (21.6 g, 0.17 mol) dropwise. The reaction mixture was stirred at room temperature for 1 hr and the solvent was removed under reduced pressure to give the title compound as crude product (22 g).

Workup

  1. customthe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-c05a799b4e774fd2af20184ae721d5c4
Source dataset
uspto-grants-2013_08
Patent number
US08513289B2

Reaction notes

Loading…