Hydrochloric Acid → HCID 136013808, compound

HRID 1894721Notes

Reaction equation

HRID 1894721 reaction equation
C([O:3][C:4]1[C:9]([C:10]2[S:14][C:13]([CH2:15][NH:16][C:17]([C:19]3[NH:20][CH:21]=[C:22]([C:24](=[O:34])[C:25]4[C:30]([F:31])=[CH:29][C:28]([F:32])=[CH:27][C:26]=4[F:33])[CH:23]=3)=[O:18])=[N:12][N:11]=2)=[CH:8][CH:7]=[CH:6][N:5]=1)C.Cl>O1CCOCC1>[O:3]=[C:4]1[C:9]([C:10]2[S:14][C:13]([CH2:15][NH:16][C:17]([C:19]3[NH:20][CH:21]=[C:22]([C:24](=[O:34])[C:25]4[C:26]([F:33])=[CH:27][C:28]([F:32])=[CH:29][C:30]=4[F:31])[CH:23]=3)=[O:18])=[N:12][N:11]=2)=[CH:8][CH:7]=[CH:6][NH:5]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 49784344HCID 49784344, compound

Product 1

HCID 136013808HCID 136013808, compoundYield 98.8%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To N-{[5-(2-ethoxypyridin-3-yl)-1,3,4-thiadiazol-2-yl]methyl}-4-(2,4,6-trifluorobenzoyl)-1H-pyrrole-2-carboxamide (example 16) (102 mg, 021 mmol) was added 3 mL of 4M hydrogen chloride in 1,4-dioxane and the resulting suspension was stirred at rt for 7 hr. The reaction mixture was concentrated. The residue was triturated from dichloromethane to give the title compound (95 mg).

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customThe residue was triturated from dichloromethane

Sources & evidence

ORD record
ord-cfb6e569cd5446288323035218204c81
Source dataset
uspto-grants-2013_08
Patent number
US08513289B2

Reaction notes

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