Tetrahydrofuran → 3-[4-(4-Methanesulfonyl-phenoxy)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidine-1-carboxylic acid tert-butyl ester

HRID 189483Notes

Reaction equation

HRID 189483 reaction equation
[C:1](=[O:2])([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])[N:8]1[CH2:9][CH:10]([OH:14])[CH2:11][CH2:12][CH2:13]1.[CH3:34][S:35](=[O:36])(=[O:37])[c:38]1[cH:39][cH:40][c:41]([O:42][c:43]2[c:44]3[c:45]([n:46][cH:47][n:48]2)[nH:49][n:50][cH:51]3)[cH:52][cH:53]1.[O:54]1[CH2:55][CH2:56][CH2:57][CH2:58]1.[c:15]1([P:16]([c:17]2[cH:18][cH:19][cH:20][cH:21][cH:22]2)[c:23]2[cH:24][cH:25][cH:26][cH:27][cH:28]2)[cH:29][cH:30][cH:31][cH:32][cH:33]1>>[C:1](=[O:2])([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])[N:8]1[CH2:9][CH:10]([n:49]2[c:45]3[c:44]([c:43]([O:42][c:41]4[cH:40][cH:39][c:38]([S:35]([CH3:34])(=[O:36])=[O:37])[cH:53][cH:52]4)[n:48][cH:47][n:46]3)[cH:51][n:50]2)[CH2:11][CH2:12][CH2:13]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 11776TriphenylphosphineHCID 5456991-Boc-3-hydroxypiperidineHCID 579650144-(4-methanesulfonyl-phenoxy)-1H-pyrazolo[3,4-d]pyrimidine

Product 1

HCID 532580283-[4-(4-Methanesulfonyl-phenoxy)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidine-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-ea31da7d432445ea8fb49a547d3f8a30
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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