Tetrahydrofuran → 2-(Pyridin-4-ylamino)-thiazole-4-carboxylic acid

HRID 1895389Notes

Reaction equation

HRID 1895389 reaction equation
C([O:3][C:4]([C:6]1[N:7]=[C:8]([NH:11][C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)[S:9][CH:10]=1)=[O:5])C.O1CCCC1.[OH-].[Na+]>CO>[N:15]1[CH:16]=[CH:17][C:12]([NH:11][C:8]2[S:9][CH:10]=[C:6]([C:4]([OH:5])=[O:3])[N:7]=2)=[CH:13][CH:14]=1

Participants

5

Reactant 3

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 27420752-(Pyridin-4-ylamino)-thiazole-4-carboxylic acid ethyl ester

Product 1

HCID 181867402-(Pyridin-4-ylamino)-thiazole-4-carboxylic acid

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-(Pyridin-4-ylamino)-thiazole-4-carboxylic acid (160 mg) was prepared according to General Procedure C using 2-(pyridin-4-ylamino)-thiazole-4-carboxylic acid ethyl ester in methanol:tetrahydrofuran:2N NaOH (1:1:1, 1.5 mL). The solvents were evaporated and the compound was dried. The crude product was used without further purification.

Workup

  1. customThe solvents were evaporated
  2. customthe compound was dried
  3. customThe crude product was used without further purification

Sources & evidence

ORD record
ord-8a86c1ceea4c4d9b870e0da0a508ccf4
Source dataset
uspto-grants-2013_08
Patent number
US08513430B2

Reaction notes

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