反应详情

A suspension of the Compound of Example 3 (100 mg, 0.47 mmol), 2-bromo-5-nitrofuran (98 mg, 0.51 mmol) and potassium carbonate (72 mg, 0.52 mmol) in DMF (2 mL) was stirred at r.t. for 4 h. Afterwards, the reaction mixture was poured into water and extracted with EtOAc. The combined organic layers were washed with brine, dried on Na2SO4 and evaporated to dryness in vacuo to afford a residue, which was purified by flash chromatography eluting with Petroleum Ether-EtOAc 6:4 affording the title product (94 mg) as a yellow solid.

1. extractionextracted with EtOAc
2. washThe combined organic layers were washed with brine
3. customdried on Na2SO4
4. customevaporated to dryness in vacuo
5. customto afford a residue, which
6. customwas purified by flash chromatography
7. washeluting with Petroleum Ether-EtOAc 6:4 affording the title product (94 mg) as a yellow solid