Triethylamine → HCID 25181653, compound

HRID 1896008Notes

Reaction equation

HRID 1896008 reaction equation
[C:1]1(/[CH:7]=[CH:8]/[CH:9]=[C:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl[C:17]1[C:22]([N+:23]([O-:25])=[O:24])=[CH:21][CH:20]=[CH:19][N:18]=1.C(N(CC)CC)C>>[N+:23]([C:22]1[C:17]([N:13]2[CH2:12][CH2:11][C:10](=[CH:9]/[CH:8]=[CH:7]/[C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)[CH2:15][CH2:14]2)=[N:18][CH:19]=[CH:20][CH:21]=1)([O-:25])=[O:24]

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 796132-Chloro-3-nitropyridineHCID 86627345HCID 86627345, compound

Product 1

HCID 25181653HCID 25181653, compoundYield 95.7%

Procedure

A well homogenised mixture of Compound 255b (175 mg, 0.878 mmol), 2-chloro-3-nitropyridine (153 mg, 0.966 mmol) and triethylamine (0.139 mL, 0.97 mmol) was stirred at 25° C. for 24 h. The reaction crude was purified by flash chromatography (EtOAc—Petroleum Ether 8:2) affording the title product (270 mg).

Workup

  1. stirringwas stirred at 25° C. for 24 h
  2. customThe reaction crude
  3. customwas purified by flash chromatography (EtOAc—Petroleum Ether 8:2)

Sources & evidence

ORD record
ord-b42f9352a8d848aea479a21e0c83407c
Source dataset
uspto-grants-2013_08
Patent number
US08518916B2

Reaction notes

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