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HRID1896030

反应详情

EQUATION

反应方程式

HRID 1896030 的结构方程式

REACTANTS

反应物

5
结构：Fc1ccccn1
HCID9746

Pyridine, 2-fluoro-

C5H4FN

结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：Cc1ccc(C#N)c(Cl)n1
HCID520400

2-Chloro-6-methylnicotinonitrile

C7H5ClN2

结构：Cc1cccc(C#CC=C2CCN(c3ccccn3)CC2)n1
HCID25181639

未命名化合物

结构：Fc1cc(F)cc(C#CC=C2CCNCC2)c1
HCID86627342

未命名化合物

PRODUCTS

生成物

1
结构：Cc1ccc(C#N)c(N2CCC(=CC#Cc3cc(F)cc(F)c3)CC2)n1
HCID86627350

未命名化合物

收率 61%

PROCEDURE

实验过程

The title compound was synthesized following the procedure reported for the compound of Example 59 replacing the compound of Example 3, 2-fluoropyridine and TEA respectively with Compound 228b, 2-chloro-6-methylnicotinonitrile and potassium carbonate. Purification by automated flash chromatography (Horizon™-Biotage) eluting with PE-EtOAc 95:5. Yellow solid. Yield: 61%

WORKUP

后处理

  1. customPurification by automated flash chromatography (Horizon™-Biotage)
  2. washeluting with PE-EtOAc 95:5