Lithium hydroxide, monohydrate → HCID 87200247, compound

HRID 1896156Notes

Reaction equation

HRID 1896156 reaction equation
C[O:2][C:3]([CH:5]([P:17]([O:21][CH3:22])([O:19][CH3:20])=[O:18])[NH:6][C:7]([O:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:8])=[O:4].O[Li:24].O>CCO.CO.O>[Li+:24].[CH2:10]([O:9][C:7]([NH:6][CH:5]([P:17]([O:21][CH3:22])([O:19][CH3:20])=[O:18])[C:3]([O-:4])=[O:2])=[O:8])[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Participants

5

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 2734718Methyl 2-{[(benzyloxy)carbonyl]amino}-2-(dimethyl phosphono)acetate

Product 1

HCID 87200247HCID 87200247, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 22242641Methanol--water (1/1)Solvent

Conditions

Temperature
0 °C

Procedure

Z-α-phosphonoglycine trimethyl ester (1.6 g) was dissolved in EtOH (5 mL) and treated with a solution of LiOH.H2O (408 mg) in MeOH/H2O (5 mL/2 mL). The mixture was stirred at 0° C. for 30 min and the solvent was removed. The crude (1.5 g) was used directly in the next step.

Workup

  1. customthe solvent was removed

Sources & evidence

ORD record
ord-21370eaee98f46bf8a073fae54e200b4
Source dataset
uspto-grants-2013_08
Patent number
US08518912B2

Reaction notes

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