Phosphorus oxychloride → HCID 59198460, compound

HRID 1896497Notes

Reaction equation

HRID 1896497 reaction equation
[Br:1][C:2]1[C:3]2[S:11][C:10]3[CH:12]=[CH:13][C:14]([Cl:16])=[CH:15][C:9]=3[C:4]=2[C:5](O)=[N:6][CH:7]=1.O=P(Cl)(Cl)[Cl:19]>>[Br:1][C:2]1[C:3]2[S:11][C:10]3[CH:12]=[CH:13][C:14]([Cl:16])=[CH:15][C:9]=3[C:4]=2[C:5]([Cl:19])=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178517586HCID 178517586, compound

Product 1

HCID 59198460HCID 59198460, compound

Procedure

A suspension of 4-bromo-8-chloro[1]benzothieno[3,2-c]pyridine-1-ol in POCl3 (1 M) was placed in a microwave reactor at 240° C. (normal absorption) for 10 min. The reaction mixture was carefully extracted with EtOAc/NaHCO3, dried over Na2SO4, filtered and evaporated to provide the title compound.

Workup

  1. customwas placed in a microwave reactor at 240° C.
  2. custom(normal absorption) for 10 min
  3. extractionThe reaction mixture was carefully extracted with EtOAc/NaHCO3
  4. dry with materialdried over Na2SO4
  5. filtrationfiltered
  6. customevaporated

Sources & evidence

ORD record
ord-e64f543bf7c84936a569846dbe210981
Source dataset
uspto-grants-2013_08
Patent number
US08518964B2

Reaction notes

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