Hydrogen Peroxide → HCID 23582563, compound

HRID 1896512Notes

Reaction equation

HRID 1896512 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][C:8]2[NH:7][C:6]3[C:11]([C:17]#[N:18])=[CH:12][N:13]=[C:14]([NH:15][CH3:16])[C:5]=3[C:4]=2[CH:3]=1.C([O-])([O-])=[O:20].[K+].[K+].OO>CS(C)=O>[F:1][C:2]1[CH:10]=[CH:9][C:8]2[NH:7][C:6]3[C:11]([C:17]([NH2:18])=[O:20])=[CH:12][N:13]=[C:14]([NH:15][CH3:16])[C:5]=3[C:4]=2[CH:3]=1

Participants

5

Reactant 3

HCID 784Hydrogen PeroxideHCID 11430Potassium CarbonateHCID 59198468HCID 59198468, compound

Product 1

HCID 23582563HCID 23582563, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Conditions

Temperature
50 °C

Procedure

8-Fluoro-1-(methylamino)-5H-pyrido[4,3-b]indole-4-carbonitrile (36 mg, 0.150 mmol) was combined with K2CO3 (55.9 mg, 0.405 mmol) and dissolved in DMSO (3 ml) followed by the addition of hydrogen peroxide (0.066 ml, 0.749 mmol). The solution was heated at 50° C. for three hr. The solution was cooled to ambient temperature directly purified by HPLC (eluted with MeCN/H2O with 1% TFA).

Workup

  1. temperatureThe solution was cooled to ambient temperature
  2. customdirectly purified by HPLC (eluted with MeCN/H2O with 1% TFA)

Sources & evidence

ORD record
ord-7e9993ab95b84eaca6f6b572ccc35bcc
Source dataset
uspto-grants-2013_08
Patent number
US08518964B2

Reaction notes

Loading…