Phosphorus oxychloride → HCID 59198433, compound

HRID 1896546Notes

Reaction equation

HRID 1896546 reaction equation
O[C:2]1[C:7]2[C:8]3[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][C:9]=3[S:10][C:6]=2[C:5]([C:19]#[N:20])=[CH:4][N:3]=1.O=P(Cl)(Cl)[Cl:23]>>[Cl:23][C:2]1[C:7]2[C:8]3[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][C:9]=3[S:10][C:6]=2[C:5]([C:19]#[N:20])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178510360HCID 178510360, compound

Product 1

HCID 59198433HCID 59198433, compound

Procedure

A suspension of 1-hydroxy-7-(trifluoromethyl)[1]benzothieno[3,2-c]pyridine-4-carbonitrile in POCl3 (1 M) was placed in a microwave reactor at 210° C. (normal absorption) for 10 min. The reaction mixture was carefully poured onto ice, stirred for 10 min and the solid filtered off to provide the title compound.

Workup

  1. customwas placed in a microwave reactor at 210° C.
  2. custom(normal absorption) for 10 min
  3. additionThe reaction mixture was carefully poured onto ice
  4. filtrationthe solid filtered off

Sources & evidence

ORD record
ord-8e7b1d0ae09a422dbeb4c5838be7000b
Source dataset
uspto-grants-2013_08
Patent number
US08518964B2

Reaction notes

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